SCHIZOPHRENIA THERAPY AND PHARMACOLOGY
NEUROLEPTICS – TYPICAL ANTIPSICHOTICS
PHENOTHIAZINES
Aliphatic side chain
- Chlorpromazine (Largactil®)
- Promazine (Talofen®)
- Levomepromazine (Nozinam®)
Piperazine side chain
- Fluphenazine (Moditen®, Anatensol®)
- Perphenazine (Trilaphon®)
- Trifluoperazine (Modalina®)
Piperidine side chain
- Thioridazine (Mellepril®)
- Periciazine (Neuleptil®)
THIOXANTENES
Aliphatic side chain
- Chlorprotiexene
Piperazine side chain
- Thiothixene
- Flupentixol (INN)
- Zuclopenthixol (Clopixol®)
PHENYLBUTYLPIPERIDINES
- Haloperidol (Serenase®)
- Doperidol (Sintodian®)
DIPHENYLBUTYLPIPERIDINE
- Pimozide (Orap®)
- Fluspirilen (Imap®)
DIBENZOOXAZEPINE
- Clotiapine (Entumin®)
- Loxapine (INN)
- Molindone (Moban®)
ATYPICAL ANTIPSYCHOTICS
- Clozapine (Moban®) Pk:100-300mg/die; Pd: 5-HT2A, H1, M.
- Olanzapine (Zyprexa®) Pk:10mg/die; Pd: 5-HT2A, M.
- Quetiapine (Seroquel®) Pk:150-750mg/bid; Pd: α1, H1.
- Risperidone (Risperdal®) Pk:2-6mg/bid; Pd: D2, 5-HT2A..
- Paliperidone (Invega®) Pk:2-6mg/bid; Pd: D2, 5-HT2A..
- Ziprasidone (Zeldox®) Pk:80-200mg/bid; Pd: D2, 5-HT2A..
- Sulpiride (Championil®) Pd:
- Aripiprazole (Abilify®)
ATYPICAL ANTIPSYCHOTICS
- H1: sedative
- 5-HT: social reintegration, insomnia, agitation.
- M: xerostomia, constipation.
- α1: orthostatic hypotension.
- D2: dizziness, insomnia.