ROTFEL

PHARMACEUTICAL LIBRARY

Antipsychotic drugs

SCHIZOPHRENIA THERAPY AND PHARMACOLOGY

NEUROLEPTICS – TYPICAL ANTIPSICHOTICS

PHENOTHIAZINES

Aliphatic side chain
  • Chlorpromazine (Largactil®)
  • Promazine (Talofen®)
  • Levomepromazine (Nozinam®)
Piperazine side chain
  • Fluphenazine (Moditen®, Anatensol®)
  • Perphenazine (Trilaphon®)
  • Trifluoperazine (Modalina®)
Piperidine side chain
  • Thioridazine (Mellepril®)
  • Periciazine (Neuleptil®)

THIOXANTENES

Aliphatic side chain
  • Chlorprotiexene
Piperazine side chain
  • Thiothixene
  • Flupentixol (INN)
  • Zuclopenthixol (Clopixol®)

PHENYLBUTYLPIPERIDINES

  • Haloperidol (Serenase®)
  • Doperidol (Sintodian®)

DIPHENYLBUTYLPIPERIDINE

  • Pimozide (Orap®)
  • Fluspirilen (Imap®)

DIBENZOOXAZEPINE

  • Clotiapine (Entumin®)
  • Loxapine (INN)
  • Molindone (Moban®)

ATYPICAL ANTIPSYCHOTICS

  • Clozapine (Moban®) Pk:100-300mg/die; Pd: 5-HT2A, H1, M.
  • Olanzapine (Zyprexa®) Pk:10mg/die; Pd: 5-HT2A, M.
  • Quetiapine (Seroquel®) Pk:150-750mg/bid; Pd: α1, H1.
  • Risperidone (Risperdal®) Pk:2-6mg/bid; Pd: D2, 5-HT2A..
  • Paliperidone (Invega®) Pk:2-6mg/bid; Pd: D2, 5-HT2A..
  • Ziprasidone (Zeldox®) Pk:80-200mg/bid; Pd: D2, 5-HT2A..
  • Sulpiride (Championil®) Pd:
  • Aripiprazole (Abilify®)

ATYPICAL ANTIPSYCHOTICS

  • H1: sedative
  • 5-HT: social reintegration, insomnia, agitation.
  • M: xerostomia, constipation.
  • α1: orthostatic hypotension.
  • D2: dizziness, insomnia.
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