ANTIDEPRESSANTS

I generation of antidepressants (1957-1970)

Monoamine oxidase inhibitors (MAOI)

Ist generation – irreversible and non selective MAOI

• Nialamide (hydrazine)
• Isocarboxazide (hydrazine)
• Phenelzine (hydrazine)
• Pargyline
• Tranylcypromine

IInd generation irreversible and selective MAOI

• Clorgiline (MAO_A inhibitor)
• Selegiline (MAO_B inhibitor)

IIIrd generation reversible and selective MAOI

• Moclobemide
• Brofaromina
• Toloxatone

Catechol-O methyl transferase inhibitors (COMTI)

• Tolcapone
• Entecapone

Tricyclic antidepressants (Thymoleptics)

• Phenothiazine (antihistaminic)
• Clorpromazine – CPZ (neuroleptic)
• Amitriptyline
• Nortriptiline
• Imipramine
• Desipramine
• Clomipramine
• Doxepin
• Dothiepin,Z- or Dosulepin
• Trimipramine
• Melitracen
• Amoxapine
• Opipramol
• Lofepramine
• Chlorprothixene

II generation of antidepressants (1970- 2000)

Selective serotonine reuptake inhibitors (SSRI)

• Fluoxetine
• Paroxetine
• Citalopram
• Escitalopram
• Sertraline
• Fluvoxamine
• Zimeldine

III generation of antidepressants

Norepinephrine reuptake inhibitors (NRI)

• Talopram
• Nisoxetine
• Atomoxetine
• Reboxetine
• Viloxazine

Serotonin/norepinephrine reuptake inhibitors (SNRI)

• Duloxetine
• Venlafaxine
• Droxidopa
• Norepinephrine

Norepinephrine/serotonine specific antidepressants (NSSA)

• Mirtazapine
• Aptazapine
• Mianserine

Other antidepressants

Serotonin precursors

• Hydroxytryptophan

Serotonine agents

• Trazodone
• Buspirone
• Gepirone