ANTIPSYCHOTIC DRUGS
Neuroleptic drugs (Typical antipsychotics)
Phenothiazine derivatives
Aliphatic
Piperidine derivatives
Piperazine derivatives
Long acting phenothiazines
Thioxanthenes
- Chlorprothixene
- Zuclopenthixol
- Flupenthixol
- Flupenthixol decanoate (long acting prodrug)
Butyrophenone
Diphenylbutylpiperidine
Time of action longer than butyrophenone. More selective on D2
Atypical antispychotics
Benzamides
Dopaminergic partial agonists
Dibenzodiazepines
Selectivity for D4. Such drugs have no extrapyramidal effects and can cause drug-induced agranulocytosis.
Other therapies
Rauwolfia alkaloids
This drugs blocks the vesicular monoamine transporter VMAT