ANTIPSYCHOTIC DRUGS

Neuroleptic drugs (Typical antipsychotics)

Phenothiazine derivatives

Aliphatic

• Chlorpromazine
• Triflupromazine

Piperidine derivatives

• Thioridazine
• Periciazine
• Pipotiazine

Piperazine derivatives

• Prochlorperazine
• Trifluoperazine
• Perphenazine
• Fluphenazine

Long acting phenothiazines

• Fluphenazine enanthate
• Fluphenazine dacanoate
• Perphenazine enanthate
• Pipotiazine palmitate

Thioxanthenes

• Chlorprothixene
• Zuclopenthixol
• Flupenthixol
• Flupenthixol decanoate (long acting prodrug)

Butyrophenone

• Haloperidol
• Haloperidol decanoate (prodrug)
• Trifluperidol
• Droperidol
• Spiperone

Diphenylbutylpiperidine

Time of action longer than butyrophenone. More selective on D2

• Pimozide
• Penfluridol
• Chlorpromazine

Atypical antispychotics

Benzamides

Dopaminergic partial agonists

• Metoclopramide
• Sulpiride
• Sultopride
• Remoxipride
• Veralipride

Dibenzodiazepines

Selectivity for D4. Such drugs have no extrapyramidal effects and can cause drug-induced agranulocytosis.

• Clozapine
• Loxapine
• Clothiapine
• Metiapine
• Olanzapine

Other therapies

Rauwolfia alkaloids

This drugs blocks the vesicular monoamine transporter VMAT

• Reserpine
• Deserpidine
• Rescinnamine

Lithium salts:

• Lithium carbonate – Li₂CO₃