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PHARMACEUTICAL LIBRARY

Drugs for treatment of Parkinson’s disease

ANTIPARKINSONIANS

Drugs that incerase the synthesis of dopamine in the CNS

Drugs that increase the release and decrease reuptake of dopamine from presynaptic ends

Drugs that decrease metabolism of dopamine

Dopaminergic agonists

Agonist D1 and D2

D2 partial agonists

Ergot derivatives

Not-ergot derivatives (better tollerated than ergot derivatives)

Dopaminergic antagonists

Used for PD to reduce peripheral side effects

Non dopaminergic therapy of Parkinson’s disease

Anticholinergic drugs for PD

Anticholinergic agents of synthesis

Antihistaminics with cholinergic action

Central myorelaxants

Neuroprotection

  • Antioxidants (vit. E & C)
  • NSAIDS (inhibitors of COX2)
  • Coenzyme Q
  • Antiapoptotic agents
  • Neurotrophic factors (GDNF-NT3)
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