DRUGS THAT MODULATE HISTAMINERGIC TRANSMISSION

Agonists

• Betazole
• Betahistine

Antagonists H₁

Ethylenediamine derivatives (X=NH)

• Phenbenzamine
• Tripelenamine
• Mepyramine
• Methaphenilene
• Methapyrilene
• Antazoline

Ethanolamine derivatives or basic ethers (X=O)

• Diphenhydramin
• Medrylaminum
• Chlordiphenidramine
• Carbinoxamine
• Clemastine

Alkyalines (derivatives of the 3-aminopropane)

• Pheniramine
• Clorpheniramine
• Brompheniramine
• Triprolidine
• Pyrrobutamine
• Triprolidine
• Triprolidine hydrochloride or Triprolidine Oxalate, (trans)-Isomer
• trans-Pyrrobutamine 1000
• cis-Pyrrobutamine 1

Piperazines

• Cyclizine
• Clorcyclizine
• Hydroxyzine
• Oxatomide

Phenothiazine or tricyclic derivatives

• Fenethazine
• Promethazine
• Cyproheptadine

II and III generation antagonists H₁

• Terfenadine
• Fexofenadine
• Astemizole
• Norastemizole
• Cetirizine
• Levoceterizine
• Loratadine
• Desloratadine

Indirect antagonist

• Sodium chromoglycate

Antagonist H₂ & Antiulcer drugs

Antagonist H₂

• Cimetidine
• Ranitidine
• Famotidine
• Tiotidine
• Nizatidine
• Imidazoles
• Dimethylaminofuran
• Guanidinothiazole
• Roxatidine
• Piperidinomethylphenoxy

Drugs that boost protective factors

• Misopristol
• Sucralfate
• Dinoprostone or PGE₂

Antacids

• Sodium bicarbonate
• Alluminum hydroxide + magnesium hydroxide
• Sodium bicarbonate + sodium alginate

Antimuscarinic drugs

• Atropine
• Atropine N-Methyl bromide
• Scopolamine

Antimuscarinic M₁ selective

• Pirenzepine
• Telenzepine (for gastric ulcer)

Proton pump inhibitors (PPI)

• Omeprazole
• Lansoprazole
• Pantoprazole
• Timoprazole
• Rabeprazole

Antagonist of the gastrin receptor CCK-B

• YM-022