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PHARMACEUTICAL LIBRARY

Sedative and hypnotic drugs

DRUGS WITH SEDATIVE AND HYPNOTIC EFFECTS

Drugs acting on GABAA receptor

GABAA receptor agonists from natural sources

  • GABA (endogenous neurotransmitter)
  • Gabaculine (neurotoxin first isolated from te bacteria streptomyces toyacaensis)
  • Muscimol (alkaloid present in the mushrooms Amanita muscaria)

GABAA receptor antagonists from natural sources

GABAA receptor endogenous allosteric modulators

Alcohols and phenols

  • Ethanol
  • Propofol (its uses include the induction and manteinance of general anaesthesia)

Aldehydes

  • Trichloroethanol (in vivo – its prodrug is chloral hydrate)
  • Chloroform (in vitro – its prodrug is chloral hydrate)
  • Paraldehyde (is a prodrug – in vivo becomes acetaldehyde which forms ethanol)

Antihistaminics

First generation of antihistaminic drugs

Barbiturates

Benzodiazepines

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