• Wed. Oct 5th, 2022

Anticancer drugs

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Non Cycle dependent agents

Alkylating agents

Classical alkylating agents

Nitrogen mustards


Nitrosoureases (urea drerivatives highly lipophylic)


Non-Classical alkylating agents

Triazenes derivatives

  • Dacarbazine
  • Temozolamide (decarbazine derivative); temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication.


Platinum compounds

Platinum compounds

  • Cisplatin
  • Carboplatin
  • Oxaliplatin


Antifolates (antifolic compounds)

  • Methotrexate (antineoplastic and immunosuppressant)
  • Pemetrexed (antineoplastic)
  • Trimethrexate (liposoluble)
  • Raltitrexed (anti-TS; antagonist of thymidine synthase)
  • Pemetreed (multitarget antifolate since it inhibit different enzymes that require folic acid)
  • Paraltrexate

Others antifolates (not anticancer)

  • Proguanil (antimalarial antifolic compound)
  • Pyrimethamine (antiprotozoal antifolic compound)
  • Trimethoprim (antibacterial antifolic compound)

Antipyrimidines (pyrimidine analoguges)

  • 5-Fluorouracil
  • Cabecitabine

Cytidine analogues

  • Cytarbabine (AraC)
  • Gemcitabine
  • Azacytidine

Antipurines (purine analogues)


  •  Mercaptopurines (first line treatment for leukemia in children)
  • Thioguanine (immunosuppressive agent)
  • Azathioprine