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PHARMACEUTICAL LIBRARY

Antibiotics

CLASSIFICATION OF ANTIBIOTICS

Cell wall synthesis inhibitors (CWSIs) antibiotics

Penicillins (β-lactam antibiotics)

Natural penicillins

Penicillinase resistant penicillins (PRP) – Anti-staphilococcal

“Narrow-spectrum” (resistant to beta-lactamase = “penicillinase” inactivation)

Broad spectrum penicillins

Aminopenicillins
Carboxypenicilins – Antipseudomonal
Uredopenicillins – Antipseudomonal

β-lactamase inhibitors

Focus on antistaphilococcal and antipseudomonal penicillins

Cephalosporins (β-lactam antibiotics)

Narrow spectrum cephalosporins (1st generation – 1G)

Expanded spectrum cephalosporins (2nd generation – 2G)

Broad spectrum cephalosporins (3rd generation – 3G)

Extended spectrum cephalosporins (4th generation – 4G)

5th generation cephalosporins – 5G

Carbapenems (β-lactam antibiotics)

Monobactams (β-lactam antibiotics)

Glycopeptides

Lipopeptides

Polipeptides

Cyclic polypeptides

Phosphoenolpyruvate analogue

  • Phosphomycin (synthetic broad spectrum bactericidal antibiotic)

Antitubercular agents

Protein synthesis inhibitors (PSIs) antibiotics

Aminoglycosides (30Sv ribosomal subunit inhibitors)

Tetracyclines (30Sv ribosomal subunit inhibitor inhibitors)

Glycylcycline (30Sv ribosomal subunit inhibitors)

Oxazolidines (50Sv ribosomal subunit inhibitors)

Macrolides (50Sv ribosomal subunit inhibitors)

Ketolides (50Sv ribosomal subunit inhibitors)

Lincosamides (50Sv ribosomal subunit inhibitors)

Streptogrammins (50Sv ribosomal subunit inhibitors)

Nucleic acid inhibitors (NAIs) antibiotics

DNA synthesis inhibitors (DNA-SIs)

Fluoroquinolones

RNA synthesis inhibitors (RNA-SIs)

Antimetabolites antibiotics

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